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Protein Production by Regenerative Pathway

Pathway Name Description Function
Angiogenesis Ang1 Angiopoietin 1 Angiogenesis and Supports VEGF
Angiogenin Ribonuclease 5 Chemotaxis, Cell Proliferation & Angiogenesis
Cathepsin S CTSS Angiogenesis and ECM Protease Activity
ENA-78 CXCL5 Wound Healing from Diabetes
I-309 CCL-1 Angiogenesis and Supports VEGF
IL-13R1 Metallothionein Antioxidant and Hypoxia Tissue Support
LAP (TGFb1) TGFb1 MSC Chemotaxis, Angiogenesis
NAP-2 Neutrophil-Activating Peptide-2 Hypoxia Response involved in PAD and CLI
PIGF Phosphatidylinositol Glycosyl Factor Angiogenesis & Cellular Homing
TGTFb1 LAP MSC Chemotaxis, Angiogenesis
uPAR CD87 Wound Healing – Tissue Regeneration
VEGF Vascular Endothelial Growth Factor Angiogenesis & Chemotaxis
VEGFR VEGF Receptor Angiogenesis
Chemotaxis & Migration 6-Ckine CCL21 Cell Migration and Chemotaxis
DR6 Death Receptor 6 Chemotaxis, Cell Migration & Anti-Cell Death
IGFBP2 Insulin Growth Factor Binding Protein #2 Supports TIMPs & MSC Migration
IGFBP3 Insulin Growth Factor Binding Protein #3 Chemotaxis and Cell Migration
IL-8 Interleukin-8 Chemotaxis, Cell Proliferation, Cell Survival
MCSF Macrophage Colony Stimulating Factor Chemotaxis, Macrophage Proliferation & Regulation
MIP-1d CCL15 Chemotaxis
PDGF-AA Platelet Derived Growth Factor Cell Survival & MSC Proliferation – Mitogenic
PF4 Platelet Factor 4 Chemoattractant and Role in Inflammation
RANTES CCL5 Chemoattractant, Modulates Inflammation
SDF-1b Stromal Cell Derived Factor Chemoattractant & Stem Cell Engraftment
TECK CCL25 Chemotaxis and Cell Homing
TSLP Thymic Stromal Lymphopoietin Inflammation and T-Cell Recruitment
Tissue Regeneration & Wound Repair Activin A INHBA Tissue Regeneration & Wound Healing
bFGF Basic Fibroblast Growth Factor Mitogenic Cell Survival and Tissue Regeneration
Cripto-1 EGF Family Member Stemness Marker – Cellular differentiation & Regeneration
Eotaxin Eosinophil Chemotactic Protein Chemotaxis – Tissue Regeneration
HGF Hepatocyte Growth Factor Wound Healing – Tissue Regeneration & Organ Survival
INHBA Activin A Tissue Regeneration & Wound Healing
PAI-1 Plasminogen Activator Inhibitor-1 Wound Repair & Inhibits Clot Removal
Tumor Suppressor CTACK Tumor Suppressor & Cell Survival
DAN Differentially Aberrant in Neuroblastoma Tumor Suppressor & Cell Survival – BMP Signal Inhibitor
FAS-L CD95L Tumor Suppressor, TNF Family & Immune System
HCC-4 CCL16 Tumor Suppression and Anti-Apoptosis
IGFBP4 Insulin Growth Factor Binding Protein #4 Tumor Suppressor & Cell Survival
IGFBP6 Insulin Growth Factor Binding Protein #6 Tumor Suppressor & Cell Survival
MSP MST1- Macrophage Stimulating 1 Tumor suppressor gene
OPN Osteopontin Tumor Suppression, ECM Production, Inflammation Mediation
Extracellular Matrix Development & Support GRO CXCL1 Cell and ECM Interactions – Slightly related to PF4 and IL-8
ICAM-1 Soluble CD54 Cell Adhesion Protein, Stabilizes Cell-Cell Interactions
ICAM-2 CD102 Cell Adhesion Protein & Immune Response
LIMPII Lysosomal Integral Membrane Protein II Cell Membrane Transport
LYVE-1 Lymphatic Vessel Endothelial HA Receptor 1 Hyaluronan Receptor – Binding Protein
NrCAM Neuronal Cell Adhesion Molecule Cellular Adhesion Protein
TIMP-1 Collagenase Inhibitor Blocks matrix breakdown
TIMP-2 Collagenase Inhibitor Blocks matrix breakdown
Inflammation &
Cell Support
DKK-1 Dickkoff-1 Tissue Development – wnt signaling
GDF-15 TGFbeta Superfamily Member Regulates Inflammation, Cell Survival and Apoptosis
IL-12p40 Interleukin-12 Binding protein Competes for IL-12 Receptor Binding
IL-1B Interleukin 1B Cell Proliferation, Differentiation, Modulates Inflammation
IL-29 Interferon lambda 1 Antiviral and immunomodulatory properties
INS Insulin Glucose Metabolism & Protein Synthesis
MIF Macrophage Migration Inhibitory Factor Immunity, Immunoregulation & Inflammation
TGFb3 Transforming Growth Factor Beta 3 Immunology – Modulates Inflammation
TNFR1 Soluble TNF Receptor Inhibits Tumor Necrosis Factor Signaling
TREM-1 Trigger Recpt Expressed on Myeloid Cells 1 Involved in acute inflammation & Cell Protection