Information for
Healthcare Providers
Direct Biologics is committed to providing the latest information on exosome scientific and clinical research. ExoFlo is an exosome allograft product isolated from bone marrow-derived MSCs that provides multiple regulatory proteins.
What are ExoFlo™ Exosomes?
Involved in cell to cell communication
Natural signals with no preservatives
Approximately 30nm – 150nm in size
Exosomes contain
More than 1,000 regulatory proteins1
- Anti-inflammatory cytokines
- Angiogenic growth factors
- Matrix regenerative signals
- Tumor suppressor signals
- Inhibitors of apoptosis
Messenger RNA (mRNA) – ON SWITCH
Translated by recipient cells into new proteins that can regulate inflammatory cells and new vessel formation
Micro RNA (miRNA) – OFF SWITCH
May inhibit mRNA of chronic inflammatory cytokines and matrix catabolic enzymes
Exosomes Are Not Small Cells
.
- ~1/1,000 the size of a cell
- Do not have a nucleus
- Cannot replicate
- Do not have metabolic activity
Why Bone Marrow MSCs?
- Peer reviewed published studies clearly indicate that BM-MSCs have a much higher safety profile and yield higher quality exosomes that deliver a more favorable profile of signaling factors vs. perinatal derived MSCs
- Bone marrow derived MSCs are a much more characterized cell source.
Over 63,000 peer reviewed papers have been published on bone marrow derived MSCs vs. up to 1,200 on perinatal derived MSCs. - Given the reported differences in safety, quality, and efficacy of exosome products, it is important for physicians to thoroughly investigate the exosome product being considered.
References
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- Contact your local Direct Biologics representative
- Physician product information
- Patient Education resources
Write us with questions or for the following information: contact your local Direct Biologics representative, physician product information, Patient Education resources
References
1. Anderson, J.D., Johansson, H.J., Graham, C.S., Vesterlund, M., Pham, M.T., Bramlett, C.S., Montgomery, E.N., Mellema, M.S., Bardini, R.L., Contreras, Z., Hoon, M., Bauer, G., Fink, K.D., Fury, B., Hendrix, K.J., Chedin, F., EL‐Andaloussi, S., Hwang, B., Mulligan, M.S., Lehtiö, J. and Nolta, J.A. (2016), Comprehensive Proteomic Analysis of Mesenchymal Stem Cell Exosomes Reveals Modulation of Angiogenesis via Nuclear Factor‐KappaB Signaling. Stem Cells, 34: 601-613. doi:10.1002/stem.2298