For Doctors

Direct Biologics is committed to providing the latest information on exosome scientific and clinical research

Discover how ExoFlo may be used in various applications including

Aesthetic procedures

Chronic non-healing wounds

Soft tissue injuries

Repetitive motion injuries

ExoFlo is an allograft exosome product derived from bone marrow-derived mesenchymal stem cells (MSCs) that carries signaling proteins that modulate inflammation. Involved in cell-to-cell communication: Natural signals with no preservatives, Approximately 30nm – 150nm

Delivery

More than 200 signaling proteins

  • Anti-inflammatory cytokines
  • Angiogenic growth factors
  • Anti-tumor signals
  • Help inhibit apotheosis (cell survival)
  • Regenerative & healing signals

Messenger RNA (mRNA) – ON Switch

  • Turn on regenerative mechanisms
  • Activate anti-inflammatory cytokines
  • Turn on angiogenic growth factors
  • Many other signals

Micro RNA (miRNA) – OFF Switch

  • Turn off chronic inflammatory cytokines
  • Turn off matrix catabolic enzymes
  • Many other signals

Exosomes Are Not Small Cells

.

  • Does not contain DNA
  • Does not contain Mitochondria
  • Does not contain Golgi Apparatus
  • ~1/1,000 the size of a cell
  • Direct cell to cell communication

White papers

View article
Direct Biologics, LLC Announces the Launch of ExoFlo Exosomes
published: 08 July 2019
https://www.newswire.com/news/direct-biologics-llc-announces-the-launch-of-exoflo-exosomes-20942231
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Current knowledge on exosome biogenesis and release description
Cell. Mol. Life Sci. (2018) 75:193–208
https://doi.org/10.1007/s00018-017-2595-9
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Exosomes Derived from Mesenchymal Stem Cells
Int. J. Mol. Sci. 2014, 15, 4142-4157; doi:10.3390/ijms15034142
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Extracellular vesicles potential roles in regenerative medicine
published: 03 December 2014
doi: 10.3389/fimmu.2014.00608
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Investigation of Content Stoichiometry Neural stem cells
PLOS ONE | DOI:10.1371/journal.pone.0146353 January 11, 2016
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Wound healing effect of adipose-derived stem cells A critical role of secretory factors on human dermal fibroblasts
Journal of Dermatological Science (2007) 48, 15—24
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Write us with questions or for the following information: contact your local Direct Biologics representative, physician product information, Patient Education resources

Write us with questions or for the following information: contact your local Direct Biologics representative, physician product information, Patient Education resources

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