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Direct Biologics is committed to providing the latest information on exosome scientific and clinical research. ExoFlo is an exosome allograft product isolated from bone marrow-derived MSCs that provides multiple regulatory proteins.

What are ExoFlo™ Exosomes?

Involved in cell to cell communication

Natural signals with no preservatives

Approximately 30nm – 150nm in size

ExoFlo is an allograft exosome product derived from bone marrow-derived mesenchymal stem cells (MSCs) that carries signaling proteins that modulate inflammation. Involved in cell-to-cell communication: Natural signals with no preservatives, Approximately 30nm – 150nm

The extensive intellectual property surrounding proprietary methods for obtaining concentrated growth factors and exosomes from human mesenchymal stem cells and their utility have made Direct Biologics a leader in therapeutic innovation around this ground breaking new technology. 

Growth Factors

Exosomes contain

More than 1,000 regulatory proteins

• Anti-inflammatory cytokines
• Angiogenic growth factors
• Anti-tumor signals
• Inhibitors of apoptosis

Messenger RNA (mRNA)

Translated by recipient cells into new proteins that can regulate inflammatory cells and new vessel formation

Micro RNA (miRNA) – OFF Switch

May inhibit mRNA of chronic inflammatory cytokines and matrix catabolic enzymes

Exosomes Are Not Small Cells

.

  • ~1/1,000 the size of a cell
  • Do not have a nucleus
  • Cannot replicate
  • Do not have metabolic activity

White Papers

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Exosome Origins: Why the Cell Source Matters
Stem Cells Regen Med. 2020; 4(1): 1-4.
https://www.researchgate.net/publication/339136421_Exosome_Origins_Why_the_Cell_Source_Matters
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Direct Biologics, LLC Announces the Launch of ExoFlo Exosomes
published: 08 July 2019
https://www.newswire.com/news/direct-biologics-llc-announces-the-launch-of-exoflo-exosomes-20942231
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Current knowledge on exosome biogenesis and release description
Cell. Mol. Life Sci. (2018) 75:193–208
https://doi.org/10.1007/s00018-017-2595-9
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Exosomes Derived from Mesenchymal Stem Cells
Int. J. Mol. Sci. 2014, 15, 4142-4157; doi:10.3390/ijms15034142
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Extracellular vesicles potential roles in regenerative medicine
published: 03 December 2014
doi: 10.3389/fimmu.2014.00608
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Investigation of Content Stoichiometry Neural stem cells
PLOS ONE | DOI:10.1371/journal.pone.0146353 January 11, 2016
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Wound healing effect of adipose-derived stem cells A critical role of secretory factors on human dermal fibroblasts
Journal of Dermatological Science (2007) 48, 15—24
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Concise Review: MSC-Derived Exosomes for Cell-Free Therapy
Stem Cells 2017;35:851–858
https://doi.org/10.1002/stem.2575

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